The Role of Melatonin in the Development of ScoliosisScoliosis is an abnormal lateral curvature of the spine often accompanied by vertebral rotation. The most common form of scoliosis is adolescent idiopathic scoliosis (AIS). It is believed that there are several, separate causes of scoliosis all with a common end result which hinders experimental research design. Although abnormal spinal curves have been produced using several methods in a variety of species, none of the curves created mimic those seen in AIS. Consequently, there is no current animal model that can be used to study this problem. In recent years, it has been shown that removal of the pineal gland in young chickens results in the development of scoliosis and that the curves produced have many of the characteristics seen in patients with AIS. This model is receiving much attention as it has much potential for developing an understanding of a mechanism by which scoliosis might be produced at least in some cases of AIS and also as a model for studying scoliosis in general. While serum melatonin levels are significantly reduced in all chickens following pinealectomy, not all the chickens develop scoliosis. While there is much evidence to suggest that removal of the pineal gland with subsequent reduction in serum melatonin levels is the cause of the scoliosis, there remains some suggestion that it might be an artifact of the extensive surgery or reduced levels of another product of the pineal gland that might be responsible. Unfortunately, the phenomenon does not appear to be duplicated following pinealectomy in mammals but, nevertheless, an understanding of the reasons why this is so would provide a large step forward in the understanding of scoliosis in humans. A model to explain the process by which reduced levels of melatonin might produce scoliosis includes the involvement and connection of melatonin with growth hormone and its subsequent effect on bone growth within the vertebrae. This is a very dynamic area of research and one where there is possibly immediate clinical application accompanied by the potential to revolutionize thinking about the treatment methods for scoliosis. Fonte: www.eurekah.comVisita il sito internet www.melatonina.it Melatonina contro la depressione stagionale Studio sulla Melatonina e insufficienza renale cronica Melatonina riduce l'infiammazione renale interstiziale e migliora l'ipertensione e ratti spontaneamente ipertesi Effetti della melatonina in menopausa Effetti della melatonina sull'impianto osseo Melatonina in Dermatologia Melatonina e insofferenza renale cronaca Melatonina l'ormone dell'oscurità Alopecia, un aiuto dalla melatonina? adolescenti come 'uccelli notturni' lo decide orologio interno Study bolsters melatonin sleep claims Melatonin elevates HDL in peri- and postmenopausal women Melatonin and the Thyroid Gland Delayed Sleep Phase Syndrome: A Melatonin Onset Disorder Heterologous Modulation of Androgen Receptor Nucleo-Cytoplasmic Shuttling by Melatonin: A Novel Mode of Regulating Androgen Sensitivity The Role of Thermoregulation in the Soporific Effects of Melatonin: A New Perspective Clinical Utility of the Antioxidant Melatonin in the Newborn The Role of Melatonin in the Development of Scoliosis Extrapineal Melatonin: Location and Role in Pathological Processes Melatonin in Winter Depression Cardiovascular Effects of Melatonin |
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