Melatonin in dermatology. Experimental and clinical aspectsFischer T, Wigger-Alberti W, Elsner P. Klinik fur Hautkrankheiten, Friedrich-Schiller-Universitat Jena.Melatonin (N-acetyl-5-methoxytryptamine) is a hormone with multiple functions in humans, produced by the pineal gland and stimulated by beta-adrenergic receptors. Serum melatonin levels exhibit a circadian rhythm with low levels during the day, rise in the evening and maximum levels at night between 2 and 4 a.m. Melatonin participates in the regulation of several physiological processes such as seasonal biological rhythm, daily sleep induction, aging and modulation of immunobiological defence reactions. Furthermore, melatonin has a highly lipophilic molecular structure facilitating penetration of cell membranes and serving as an extra- and intracellular free radical scavenger. Melatonin seems to quench mainly hydroxyl radicals, the most damaging of all free radicals. Melatonin may play a role in the etiology and treatment of several dermatoses e.g. atopic eczema, psoriasis and malignant melanoma. The influence of melatonin on hair growth is another aspect. Topical application of melatonin inhibits the development of UV-erythema. Penetration through skin after topical application and oral bioavailability auxit further investigations on the pharmacokinetic and pharmacodynamic actions of melatonin. Publication Types: Review Review, Tutorial PMID: 10068925 [PubMed - indexed for MEDLINE] Visita il sito internet www.melatonina.it Melatonina contro la depressione stagionale Studio sulla Melatonina e insufficienza renale cronica Melatonina riduce l'infiammazione renale interstiziale e migliora l'ipertensione e ratti spontaneamente ipertesi Effetti della melatonina in menopausa Effetti della melatonina sull'impianto osseo Melatonina in Dermatologia Melatonina e insofferenza renale cronaca Melatonina l'ormone dell'oscurità Alopecia, un aiuto dalla melatonina? adolescenti come 'uccelli notturni' lo decide orologio interno Study bolsters melatonin sleep claims Melatonin elevates HDL in peri- and postmenopausal women Melatonin and the Thyroid Gland Delayed Sleep Phase Syndrome: A Melatonin Onset Disorder Heterologous Modulation of Androgen Receptor Nucleo-Cytoplasmic Shuttling by Melatonin: A Novel Mode of Regulating Androgen Sensitivity The Role of Thermoregulation in the Soporific Effects of Melatonin: A New Perspective Clinical Utility of the Antioxidant Melatonin in the Newborn The Role of Melatonin in the Development of Scoliosis Extrapineal Melatonin: Location and Role in Pathological Processes Melatonin in Winter Depression Cardiovascular Effects of Melatonin |
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